产品货号：
Z10120
中文名称：
5 Lipoxygenase/ALOX5抗体
英文名称：
Anti-5 Lipoxygenase/ALOX5 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-5 Lipoxygenase/ALOX5 Antibody |
| 指标别名 | 5 Lipoxygenase;5 LO;5 LOX;5LPG;ALOX5;LOG5 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC |
| 基因名称 | ALOX5 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human ALOX5(650-667aa AERNKKKQLPYYYLSPDR),different from the related rat and mouse sequences by two amino acids. |
| 实际分子量 | 78KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | ALOX5(ARACHIDONATE 5-LIPOXYGENASE),also known as LOG5 or 5-LO(5-LIPOXYGENASE),is an enzyme that in humans is encoded by the ALOX5 gene.ALOX5 is a member of the lipoxygenase family of enzymes which also transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases.The enzyme 5-lipoxygenase catalyzes 2 reactions in the formation of leukotrienes.The ALOX5 gene is mapped to chromosome 10q11.21 based on an alignment of the ALOX5 sequence with the genomic sequence.Human 5-LO contains 3 nuclear localization sequences(NLSs) and a phosphorylation site involved in nuclear localization.Compared with age-matched 5-LO competent mice,the 5-LO knockout mice developed less right heart hypertrophy.Pharmacologic inhibition or ALOX5 gene disruption resulted in a significant decrease of beta-amyloid production and gamma-secretase levels.ALOX5 activity is short-lived,apparently in part because of an intrinsic instability of the enzyme. |
| Uniprot ID | P09917 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | arachidonate 5-lipoxygenase |
| 蛋白名全称 | Arachidonate 5-lipoxygenase(5-LO/5-lipoxygenase) |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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